magnetic nanoporous silica as carriers for ibuprofen: adsorption and release study

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abstract

a carrier system based on nanoporous silica (sba-15) with magnetic nanoparticles of cofe2o4 was synthesized via the impregnation of cobalt salt, iron salt and citric acid with as-synthesized sba-15. the obtained samples were characterized by small angle x-ray scattering (saxs), n2 adsorption/desorption, scanning electron microscopy (sem), vibrating sample magnetometer (vsm) and ultraviolet (uv) spectroscopy.the effect of magnetization on the drug release behavior of sba-15 has been studied. ibuprofen was chosen as a model drug. drug release studies in simulated body fluid (sbf) at ph 7.4 showed that after 48 hours, the percentage of drug release through sba-15 and magnetic sba-15 could reach up to 80% and 20%, respectively. the obtained results reveal that the magnetization leads towards significant decrease of the drug release rate.

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Journal title:

international journal of bio-inorganic hybrid nanomaterials

جلد ۳، شماره ۲، صفحات ۷۵-۸۰

Keywords

[ ' s b a ' , 1 5 , ' c o f e 2 o 4 ' , ' i b u p r o f e n ' , ' d r u g r e l e a s e ' , ' m a g n e t i s m ' ]

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